Consortium for Mathematics and its Applications

Product ID: Model Reality Check
Supplementary Print

Mathematical Modeling of Patch Transdermal Drug Delivery Systems

Author: Paul J. Laumakis & ValerieW. Cross


We detail two different mathematical solution techniques for a system of first-order differential equations used to model the diffusion of a drug in a transdermal drug delivery system. We include derivation of the mathematical model from first principles involving conservation of mass and the differential form of the continuity equation, along with a description of patch delivery systems. The mathematical solution using eigenvalues and eigenvectors matches results using the Laplace transform method. A main contribution of this work is that an application of the model is presented using experimentally-obtained data associated with nicotine-patch delivery systems, and we obtain excellent agreement between the model and empirical data.
©2021 by COMAP, Inc.
The UMAP Journal 42.1
18 pages

Mathematics Topics:

Application Areas:

  • Medical, Pharmacology, Biomedical, Medicine

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